How Lithium Orotate Works

How does lithium orotate work?

Lithium orotate releases the lithium ion into the plasma and brain just like pharmaceutical lithium carbonate and lithium citrate. This is exactly the same way prescription lithium works, albeit without the toxicity.

Lithium orotate, mania, norepinephrine

Lithium orotate also reduces norepinephrine by reducing sensitivity in the postsynaptic norepinephrine receptor. Less sensitive, the receptor is less likely to receive norepinephrine and less norepinephrine transfers throughout the body. Lithium orotate also increases the uptake of norpinephrine into synaptosomes. Synaptosomes are pinched off nerve endings that cannot release hormones such as norpinephrine. Though it is known to reduces norpinephrine is remains unknown as to exactly how this comes about. Less norpinephrine reduces mania (Van Praag, 1977).

Lithium orotate, mania, dopamine

A paper published in the January 11th issue of Cell, a Duke Medical Center team has found that lithium interrupts the signaling of one of the D2 dopamine receptors in the brain. Elevated dopamine causes people to act impulsively and erratically. Lithium orotate, citrate, carbonate also inhibits the glycogen synthase kinase 3 (GSK-3) enzyme which is important in the cell's response to many signaling molecules. By destabilizing the D2 / GSK3 signaling pathway complex mania is reduced.

lithium orotate, bipolar, omega oils: synergy

Current research has provided clear evidence that lithium reduces brain inflammation by recalibrating DHA—healthy Omega 3 fatty acid. Anyone diagnoses with bipolar disorder should seriously consider a steady diet of omega acids via supplementation or fish, flax and nut diet. The National Institute of Aging examined brain samples via mass spectrometry analysis demonstrated how a six-week lithium treatment reduced inflammatory arachidonic acid levels. They also discovered that lithium the 17-OH-DHA metabolite formed from the omega-3 fatty acid is also the precursor to a wide range of anti-inflammatory compounds known as docosanoids. (Aspirin, the most popular anti-inflammatory protocol, has been shown to enhance docosanoids). Omega oil DHA concentration did the opposite. By reducing both pro-inflammatory arachindonic acid and docosanoids and increasing anti-inflammatory DHA, lithium can exert a double-protective effect creating a powerful synergy against bipolar affliction.

Lithium Orotate and Mitochondria

Lithium Orotate benefits manic depression in the human body by facilitating lithium absorption into the mitochondria—the powerhouse of our cells. Natural lithium, Lithium orotate, also stabilizes lysosome membranes which attenuates the enzymatic reaction that induce negative side effects characteristic of other forms of lithium. Lithium Orotate is not a drug, it is a naturally occurring mineral, like calcium and sulfur. Like any other mineral lithium is a fundamental requirement for mental and physical health. Most people are only aware of the pharmaceutical forms of lithium (lithium carbonate and lithium citrate) for the treatment of bipolar disorder and bipolar mania. Lithium Orotate is very different than these other forms of the mineral which require high doses to penetrate our cells. Lithium Orotate has over a 90% absorption rate so extremely low doses are needed to be effective. Lithium Orotate via nasal form is even more absorbable. It penetrates faster and given the advanced delivery system requires smaller doses. Moreover, Symmetry is designed to help the body to release more of your own lithium, an even healthier way to go. There are no side effects.





Health Benefits of Lithium Orotate

Brain Protection: Studies show that the mineral lithium can actually rejuvenate and build the grey matter nerve cells in the brain by up to three percent.

Anti-Aging Effects: Small amounts of lithium orotate have been shown to offer anti-aging effects to the brain.

Neuroprotection From Environmental Toxins: Lithium has been shown to protect the system from numerous toxins, particularly in the grey matter of the brain.

Lithium Orotate Supports Mania and Bipolar Affliction

Bipolar disorder (manic-depressive illness) is a mood disorder that involves episodes of both manic highs and seriously low mood swings, (And then back again) with periods of normalcy in between. The third most common mood disorder (after major depression and dysthymic disorder) manic-depression is often severe and life threatening. It affects about 1% of adults during their lifetime. Symptoms of manic depression typically begin during adolescence or early adulthood, and continue to recur throughout life. Men and women are equally likely to develop this disabling illness. Manic depression is often complicated by co-occurring alcohol or substance abuse. Without effective treatment, bipolar illness leads to suicide in nearly 20% of cases.

Lithium is the most effective element used for stabilizing mood swings for those with manic (bipolar) depression. Lithium Orotate, a natural Lithium salt of orotic acid, is 20 times more bio-active than other Lithium salts and allows a reduction in dosage as well as the likelihood of potential side effects associated with prescription Lithium. HBC's Symmetry is the first ever homeopathic Lithium Orotate homeopathic spray formulation. Synergistically combined with both GABA and Albumin, Symmetry is designed to help you instantly achieve therapeutic brain Lithium concentrations while supporting balanced brain function, especially during episodes of anxiety, stress, depression.

How does Lithium Orotate compare to Lithium Carbonate and Lithium Chloride?

The pharmacokinetics of Lithium Orotate were studied in parallel protocols with both the Lithium Carbonate and the Lithium Chloride ions. No differences in the uptake, distribution and excretion of the Lithium ion were observed between Lithium Orotate, Lithium Carbonate and Lithium Chloride after single injection or after administration of the Lithium salts for 20 days in the food. The findings oppose the notion that the pharmacokinetics of the Lithium ion given as Lithium Orotate differ from Lithium Chloride or Lithium Carbonate. Further more, unlike the carbonate and chloride, the oratate was found to be non toxic.

JAMA (The Journal of American Medical Association--Click here to read full study) Lithium, an inexpensive drug for bipolar disorder. Lithium is one of the most common elements used for stabilizing mood swings, mania and depression. Lithium Orotate is a highly bioavailable form of Lithium that is available without a prescription. Because of its superior bioavailability, (20 times more bio-active than other Lithium salts) lower doses of Lithium Orotate (Rather than Lithium carbonate or Lithium citrate) may be used to achieve therapeutic brain Lithium concentrations and relatively stable serum concentrations. (1,2) while greatly reducing the likelihood and severity of potential side effects

Lithium Orotate has also been demonstrated to be of benefit in the treatment of alcoholics, and proved useful in alleviating alcohol-related symptoms of liver dysfunction, seizure disorders, headaches, hyperthyroidism, affective disorders. (3) Meniere’s syndrome, and liver and lung cancers. If you cannot tolerate higher doses of Lithium due to side effects you might try replacing it with Lithium Orotate. It requires no blood tests and side effects are pretty much non-existent. It is non-prescription and even at lower doses is just as effective as much higher doses of the prescription forms of Lithium.

Standard dose is 2-6 sprays per day or as directed by your physician.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Refrences:1. Dean W. and English J., 'Lithium Orotate: The Unique, Safe Mineral with Multiple Uses,' Vitamin Research News, July, 1999.2. Kling MA, Manowitz P, Pollack IW. Rat brain and serum Lithium concentrations after acute injections of Lithium carbonate and Orotate. J Pharm Pharmacol 1978 Jun;30(6):368-70. 3. Sartori HE., Lithium Orotate in the treatment of alcoholism and related conditions. Alcohol 1986 Mar-Apr;3(2):97-100.Cautions: Lithium should not be used by individuals with significant renal or cardiovascular diseases, severe debilitation or dehydration, or sodium depletion, and by individuals who are taking diuretics or ACE inhibitors. Consult your doctor before use if you are taking anti-hypertensive drugs, anti-inflammatory drugs, analgesic drugs or insulin. Lithium should not be used by pregnant women and breast-feeding mothers. Restrictions: Not available in Canada


Lithium Orotate May Also Support:

  • Lyme's Disease

  •  Low white blood cell counts

  •  Juvenile convulsive disease

  • Alcoholism and liver disorders

  •  Pain associated with migraine and cluster headaches

  •  Hyperthyroidism and other thyroid diseases: Studies show that lithium may aid in the even distribution of iodine.

  •  Post-Traumatic Stress Disorder (PTSD), as well as a general stress reducer.

  • Attention Deficit Hyperactivity Disorder (ADHD) and Attention Deficit Disorder (ADD) and aggression: Studies show that individuals taking Lithium experienced lowered levels of rage and anger, as well as improved memory.

  •  Alzheimer’s disease and dementia

  •  In the reduction of myopia (nearsightedness) and glaucoma: Dr. Hans Nieper found that glaucoma patients could benefit from the dehydrating effect of lithium on the eye, offering patients vision improvement and a lowering of intraocular pressure.

  •  Bipolar disorder: Orotates may lessen effects of manic or depressive episodes. Lithium has been shown to serve as an effective mood balancer in 70-80 percent of bipolar patients.

  •  Depression: the therapeutic dosage of lithium Orotate is 150 mg/day. This is compared to 900-1800 mg of the prescription forms. In this dosage range of lithium orotate, there are no adverse side effects and no need for monitoring blood serum.


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Nasal Spray  Mailing Address  255 South Grand Ave. Suite 1916  Los Angeles CA 90012

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Lucky Vitamin 18 West Mount Kirk Avenue Norristown, PA 19403 USA Advanced Research Lithium Orotate 120 mg. - 200 Tablets

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